KPV Re-Usable Pen Kit
KPV Research Peptide Kit
By Antitides ResearchPeptide solutions for every animal
Peptide Name: KPVSequence: Lysine–Proline–ValineCAS Number: 67727-97-3Chemical Name: (2S)-2-[[(2S)-1-[(2S)-2,6-diaminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoic acid
Research Highlights
KPV is a naturally occurring tripeptide derived from the C-terminal region of alpha-melanocyte-stimulating hormone, also known as alpha-MSH. It has become a peptide of interest in inflammation, gut-barrier, antimicrobial, skin, and tissue-recovery research.
For equine and veterinary research, KPV is especially relevant because horses are frequently studied in relation to gut integrity, inflammatory stress, skin and coat condition, wound recovery, performance recovery, and immune response regulation. Current published KPV evidence is mainly preclinical, including cell-based studies and animal models, rather than direct clinical trials in horses.
Key Research Areas
Intestinal Inflammation & Gut Barrier ResearchKPV has been studied for its role in reducing inflammatory signaling in intestinal epithelial and immune cells. A major Gastroenterology study found that KPV can be transported via the PepT1 peptide transporter and reduced inflammation in experimental mouse colitis models. This makes KPV particularly relevant for gut-barrier and intestinal inflammation research in performance-animal contexts.
NF-kappaB & Inflammatory SignalingResearch suggests KPV may help downregulate inflammatory pathways, including NF-kappaB-related signaling, which is a central pathway involved in inflammatory responses. This mechanism is one of the main reasons KPV is studied in inflammation-focused peptide research.
Skin, Coat & Dermatology ResearchAs a fragment of alpha-MSH, KPV is linked to melanocortin research, a field that includes skin immune regulation, inflammation, barrier response, and wound biology. Reviews on alpha-MSH and related melanocortin peptides support their relevance in cutaneous inflammation and tissue-response research.
Antimicrobial Research InterestKPV and related melanocortin fragments have been investigated for antimicrobial activity, including against selected bacterial and fungal organisms. This supports its use as a research peptide in studies involving microbial balance, innate immunity, and tissue-protection pathways.
Mucosal Healing & Recovery ResearchA hyaluronic-acid nanoparticle KPV study reported combined effects against experimental ulcerative colitis by reducing inflammation and supporting mucosal healing in preclinical models. This is relevant to broader research into recovery, gut integrity, and tissue repair pathways.
Equine Research Positioning
KPV is not a registered veterinary medicine and should not be presented as a treatment for horses. However, it is a strong candidate for equine-focused peptide research because its studied mechanisms overlap with areas of major interest in horses, including:
Gut-barrier integrity and intestinal inflammatory models
Immune-signaling and inflammatory-response pathways
Skin, coat, and wound-recovery research
Performance recovery and tissue-stress research
Microbial and mucosal defense pathways
Kit Includes
1x V1 All-Metal Reusable Research Pen1x KPV Lyophilised Peptide Vial1x 3 ml Cartridge1x Travel Case1x Reconstitution Kit20x Alcohol Swabs20x Pen TipsAdditional pen tips available separately.
SAHPRA / Research Disclaimer
This product has not been evaluated by the South African Health Products Regulatory Authority. This product is not intended to diagnose, treat, cure, or prevent any disease in humans or animals.
For laboratory research use only. Not for human or animal consumption. Not for veterinary treatment or diagnostic use.
Peer-Reviewed Research References
Dalmasso G. et al. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. 2008.
Dalmasso G. et al. PepT1-Mediated Tripeptide KPV Uptake Reduces Intestinal Inflammation. Full text, PMC.
Xiao B. et al. Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis. Molecular Therapy. 2017.
Luger T.A. et al. New insights into the functions of alpha-MSH and related peptides in the immune system. Annals of the New York Academy of Sciences.
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1749-6632.2003.tb03172.x
Böhm M. et al. Melanocortin receptor ligands: new horizons for skin biology and clinical dermatology. Journal of Investigative Dermatology.
https://www.jidonline.org/article/S0022-202X%2815%2933041-4/fulltext
